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Research Opportunities in Molecular & Cellular Biology
Development, Degeneration, Regeneration
- regulation of neurons and glia
- primate development, sexuality and psychopathology
- role of neurotrophins
- CNS glycoproteins and proteoglycans
- chemosensory epithelia
- formation of synaptic connections in optic nerve regeneration
- heart muscle development
- developmental regulation of globin gene expression
- neuromuscular degeneration
- pancreatic beta cell regeneration, model for TYPE I Diabetes
- neurodegenerative disorders
Proteins and Nucleic Acids
- interactions in transcription
- protein-DNA recognition
- structural changes in proteins associated with differentiation, development and disease
- molecular chaperone-mediated protein folding, targeting and translocation
- design of nucleoside analogues as enzyme inhibitors
- mechanism of protease and protease inhibitor interactions
Biology of Membranes & Cells and Modeling
- hormonal regulation of active transport across membranes
- ionic channels of mammalian visceral smooth muscles
- optical imaging of cellular energetics
- epithelial cell polarity biogenesis
- chemosensory transduction and sensory coding
- PKC isozymes in growth factor-mediated signal transduction
- regulation of nicotinic acetylcholine receptor
- mechanism of endocytosis
- computer modeling
The Immunological Response and Cancer Biology
- regulation of IgE responses in vivo and in vitro
- the role of leukocytes, cytokines and epithelia
- mechanisms of cell activation: platelets and neurons
- mechanisms of lymphocyte-mediated tumor cell and allograft destruction
- genes and growth factors in tumorigenesis
- protooncogene and human retrovirus
Gene Expression
- regulation
- RNA polymerase/promoter interactions
- regulation by interferons
- control of transcription factors in yeast
- mechanism of DNA damage and repair
- effects of ionizing radiation
- molecular genetics
- chromosome non-disjunction and effects of gene dosage
- eukaryotic translation initiation
- regulation of mammalian Na, K-pump genes
- biology of animal RNA viruses
- evolution of RNA viruses
- exit from the mitotic cycle and entry into meiosis
Muscle and Cardiovascular Biology
- molecular basis of muscle contraction
- muscle and non-muscle motility
- regulation of gene expression in normal and diseased heart muscle
- endothelium-derived relaxing factor
- mechanism of action of vasodilators
- electrophysiological effects of anti-arrhythmic agents on channels using patch clamp
- cardiac cell membrane electrophysiology, normal and abnormal excitation
- excitation-contraction coupling in the heart
- microcirculation, cardiovascular effects of Mg2+
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